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The fast growth of cloud computing has attracted more companies to migrate their in-house IT applications into cloud and it also occurs in the medical field. A mobile healthcare system with cloud offloading is considered in this paper and it can be divided into two stages: sensor network and cloud offloading. In the first stage, information collected by body sensors should be transmitted to a remote mobile device. In order to save energy, an energy-efficient transmission scheme called cooperative multi-input multi-output (MIMO) is constructed for the data transfer when allowing individual sensor nodes to cooperate with each other. In the second stage, two offloading schemes called self-reliant multi-cloud offloading system and multi-cloud offloading system are proposed and further analyzed based on serve topology and optimal graph partition. The former provides stability but with high communication cost, while the …