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David A. Lewis*‡ and Jeffrey A. Lieberman†‡* Departments of Psychiatry and Neuroscience University of Pittsburgh School of Medicine this syndrome is increased as well. Recently, chromo-† Departments of Psychiatry, Pharmacology, some 1q21–22 was identified as the location of a major and Radiology vulnerability locus for familial schizophrenia with suffi-University of North Carolina School of Medicine cient power to permit positional cloning of the underlying gene (s)(Brzustowicz et al., 2000). Environmental factors (including exposure to infectious, autoimmune, toxic, or traumatic insults and stress Introduction during gestation or childhood) also may play a role in Schizophrenia is a brain disorder that is expressed in the pathogenesis of schizophrenia, perhaps via subtle the form of abnormal mental functions and disturbed alterations of neurodevelopment (Marcelis et al., 1998). behavior. These manifestations …