作者
Max L Senders, Sophie Hernot, Giuseppe Carlucci, Jan C van de Voort, Francois Fay, Claudia Calcagno, Jun Tang, Amr Alaarg, Yiming Zhao, Seigo Ishino, Anna Palmisano, Gilles Boeykens, Anu E Meerwaldt, Brenda L Sanchez-Gaytan, Samantha Baxter, Laura Zendman, Mark E Lobatto, Nicolas A Karakatsanis, Philip M Robson, Alexis Broisat, Geert Raes, Jason S Lewis, Sotirios Tsimikas, Thomas Reiner, Zahi A Fayad, Nick Devoogdt, Willem JM Mulder, Carlos Pérez-Medina
发表日期
2019/10
期刊
JACC: Cardiovascular Imaging
卷号
12
期号
10
页码范围
2015-2026
出版商
American College of Cardiology Foundation
简介
Objectives
This study sought to develop an integrative positron emission tomography (PET) with magnetic resonance imaging (MRI) procedure for accurate atherosclerotic plaque phenotyping, facilitated by clinically approved and nanobody radiotracers.
Background
Noninvasive characterization of atherosclerosis remains a challenge in clinical practice. The limitations of current diagnostic methods demonstrate that, in addition to atherosclerotic plaque morphology and composition, disease activity needs to be evaluated.
Methods
We screened 3 nanobody radiotracers targeted to different biomarkers of atherosclerosis progression, namely vascular cell adhesion molecule (VCAM)-1, lectin-like oxidized low-density lipoprotein receptor (LOX)-1, and macrophage mannose receptor (MMR). The nanobodies, initially radiolabeled with copper-64 (64Cu), were extensively evaluated in Apoe–/– mice and atherosclerotic …
学术搜索中的文章
ML Senders, S Hernot, G Carlucci, JC van de Voort… - JACC: Cardiovascular Imaging, 2019