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Compared with other insulin regimens, combination therapy with oral hypoglycemic agents and bedtime insulin produces similar improvement in glycemic control but induces less weight gain.

To determine whether bedtime insulin regimens differ with respect to their effects on weight gain in patients with type 2 diabetes.

Randomized, controlled trial.

Four outpatient clinics at central hospitals.

96 patients (mean age, 58 ± 1 years; mean body mass index, 29 ± 1 kg/m²) whose type 2 diabetes was poorly controlled with sulfonylurea therapy (mean glycosylated hemoglobin value, 9.9% ± 0.2%; mean fasting plasma glucose level, 11.9 ± 0.3 mmol/L [214 ± 5 mg/dL]).

Random assignment to 1 …