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Target‐controlled infusion (TCI) anesthesia using target effect‐site concentration rather than plasma concentration provides less drug consumption, safer anesthesia, less undesired side effects and improved animal welfare. The aim of this study was to calculate the constant that converts propofol plasma into effect‐site concentration (k_e0) in dogs, and to implement it in a TCI system and compare it with the effect on the central nervous system (CNS). All dogs were subjected to general anesthesia using propofol. Fourteen dogs were used as the pilot group to calculate k_e0, using the t_peak method. Fourteen dogs were used as the test group to test and validate the model. Rugloop ii^® software was used to drive the propofol syringe pump and to collect data from S/5 Datex monitor and cerebral state monitor. The calculated k_e0 was incorporated in an existing pharmacokinetic model (Beths Model). The relationship …