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The goal of this study was to obtain models that described the relation between the anaesthetic drug infusions (propofol) and an electroencephalogram (EEG) derived index (Cerebral State Index -CSI) during general anaesthesia in dogs. The first phase integrated the adaptation of hardware for EEG acquisition and exploration for the best electrodes position in dogs skull. The clinical protocol implementation and data collection were the next steps followed by CSI modeling. CSI showed adequate response to changes in drug infusion, reflecting the changes of depth of anaesthesia in dogs. The models obtained adjusted well to the original CSI data and also predicted the CSI trend during surgery. Using this monitor in current practice might improve quality in the anaesthesia procedure providing a useful tool to administer a correct sedation.