作者
Karim Asehnoune, Philippe Seguin, Jeremy Allary, Fanny Feuillet, Sigismond Lasocki, Fabrice Cook, Hervé Floch, Russell Chabanne, Thomas Geeraerts, Claire Roger, Pierre F Perrigault, Jean L Hanouz, Anne C Lukaszewicz, Matthieu Biais, Perrine Boucheix, Claire Dahyot-Fizelier, Xavier Capdevila, Pierre J Mahe, Pascale Le Maguet, Catherine Paugam-Burtz, Soizic Gergaud, Benoit Plaud, Jean M Constantin, Yannick Malledant, Laurent Flet, Veronique Sebille, Antoine Roquilly
发表日期
2014/9/1
期刊
The Lancet Respiratory medicine
卷号
2
期号
9
页码范围
706-716
出版商
Elsevier
简介
Background
Hospital-acquired pneumonia is common after traumatic brain injury, and might be partly a result of traumatic brain injury-induced adrenal insufficiency. We tested the efficacy of low-dose hydrocortisone with fludrocortisone for the prevention of hospital-acquired pneumonia.
Methods
We did this double-blind, phase 3, placebo-controlled trial in 19 intensive care units in France. We enrolled patients aged 15–65 years in the first 24 h after severe traumatic brain injury (Glasgow coma scale score ≤8 and trauma-associated lesion on brain CT scan). Patients were randomly assigned (1:1; fixed blocks of 12, stratified by centre and mechanism, Glasgow coma scale, age, and arterial pressure [MGAP] score) to receive either hydrocortisone (200 mg per day tapered) and fludrocortisone (50 μg tablet once per day) or matching placebo for 10 days. Before receiving study drug, adrenal function was assessed with a …
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K Asehnoune, P Seguin, J Allary, F Feuillet, S Lasocki… - The Lancet Respiratory medicine, 2014