作者
Anna Z Wec, Daniel Wrapp, Andrew S Herbert, Daniel P Maurer, Denise Haslwanter, Mrunal Sakharkar, Rohit K Jangra, M Eugenia Dieterle, Asparouh Lilov, Deli Huang, Longping V Tse, Nicole V Johnson, Ching-Lin Hsieh, Nianshuang Wang, Juergen H Nett, Elizabeth Champney, Irina Burnina, Michael Brown, Shu Lin, Melanie Sinclair, Carl Johnson, Sarat Pudi, Robert Bortz III, Ariel S Wirchnianski, Ethan Laudermilch, Catalina Florez, J Maximilian Fels, Cecilia M O’Brien, Barney S Graham, David Nemazee, Dennis R Burton, Ralph S Baric, James E Voss, Kartik Chandran, John M Dye, Jason S McLellan, Laura M Walker
发表日期
2020/8/7
期刊
Science
卷号
369
期号
6504
页码范围
731-736
出版商
American Association for the Advancement of Science
简介
Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs) are urgently needed. To gain a deeper understanding of cross-neutralizing antibody responses, we mined the memory B cell repertoire of a convalescent severe acute respiratory syndrome (SARS) donor and identified 200 SARS coronavirus 2 (SARS-CoV-2) binding antibodies that target multiple conserved sites on the spike (S) protein. A large proportion of the non-neutralizing antibodies display high levels of somatic hypermutation and cross-react with circulating HCoVs, suggesting recall of preexisting memory B cells elicited by prior HCoV infections. Several antibodies potently cross-neutralize SARS-CoV, SARS-CoV-2, and the bat SARS-like virus WIV1 by blocking receptor attachment and inducing S1 shedding. These antibodies represent promising candidates for therapeutic intervention and reveal a target for the …
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AZ Wec, D Wrapp, AS Herbert, DP Maurer… - Science, 2020