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In this study, a new group method of data handling (GMDH) method, based on adaptive neurofuzzy inference system (ANFIS) structure, called ANFIS-GMDH and its application for diabetes mellitus forecasting is presented. Conventional neurofuzzy GMDH (NF-GMDH) uses radial basis network (RBF) as the partial descriptions. In this study the RBF partial descriptions are replaced with two input ANFIS structures and backpropagation algorithm is chosen for learning this network structure. The Prima Indians diabetes data set is used as training and testing sets which consist of 768 data whereby 268 of them are diagnosed with diabetes. The result of this study will provide solutions to the medical staff in determining whether someone is the diabetes sufferer or not which is much easier rather than currently doing a blood test. The results show that the proposed method performs better than the other models such as multi …