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The purpose of this paper is to develop a framework which can sustain local conditions of developing countries. Design and implementation of sustainable telemedicine information systems is still a big challenge for most developing countries, despite of its wide usage in the developed countries. While various frameworks exist, not much of them have adequately addressed the issue of design for sustainability. This paper proposes an appropriate framework, which will guide telemedicine information systems designers on designing telemedicine systems that are sustainable in local conditions of developing countries. The proposed paper mainly works in the area of information systems design for sustainability, from a developing country perspective. The main factor for designing sustainable telemedicine information systems in developing countries were identified as the speed, ease to use and affordable.