作者
Caroline M Nievergelt, Adam X Maihofer, Torsten Klengel, Elizabeth G Atkinson, Chia-Yen Chen, Karmel W Choi, Jonathan RI Coleman, Shareefa Dalvie, Laramie E Duncan, Joel Gelernter, Daniel F Levey, Mark W Logue, Renato Polimanti, Allison C Provost, Andrew Ratanatharathorn, Murray B Stein, Katy Torres, Allison E Aiello, Lynn M Almli, Ananda B Amstadter, Søren B Andersen, Ole A Andreassen, Paul A Arbisi, Allison E Ashley-Koch, S Bryn Austin, Esmina Avdibegovic, Dragan Babić, Marie Bækvad-Hansen, Dewleen G Baker, Jean C Beckham, Laura J Bierut, Jonathan I Bisson, Marco P Boks, Elizabeth A Bolger, Anders D Børglum, Bekh Bradley, Megan Brashear, Gerome Breen, Richard A Bryant, Angela C Bustamante, Jonas Bybjerg-Grauholm, Joseph R Calabrese, José M Caldas-de-Almeida, Anders M Dale, Mark J Daly, Nikolaos P Daskalakis, Jürgen Deckert, Douglas L Delahanty, Michelle F Dennis, Seth G Disner, Katharina Domschke, Alma Dzubur-Kulenovic, Christopher R Erbes, Alexandra Evans, Lindsay A Farrer, Norah C Feeny, Janine D Flory, David Forbes, Carol E Franz, Sandro Galea, Melanie E Garrett, Bizu Gelaye, Elbert Geuze, Charles Gillespie, Aferdita Goci Uka, Scott D Gordon, Guia Guffanti, Rasha Hammamieh, Supriya Harnal, Michael A Hauser, Andrew C Heath, Sian MJ Hemmings, David Michael Hougaard, Miro Jakovljevic, Marti Jett, Eric Otto Johnson, Ian Jones, Tanja Jovanovic, Xue-Jun Qin, Angela G Junglen, Karen-Inge Karstoft, Milissa L Kaufman, Ronald C Kessler, Alaptagin Khan, Nathan A Kimbrel, Anthony P King, Nastassja Koen, Henry R Kranzler, William S Kremen, Bruce R Lawford, Lauren AM Lebois, Catrin E Lewis, Sarah D Linnstaedt, Adriana Lori, Bozo Lugonja, Jurjen J Luykx, Michael J Lyons, Jessica Maples-Keller, Charles Marmar, Alicia R Martin, Nicholas G Martin, Douglas Maurer, Matig R Mavissakalian, Alexander McFarlane, Regina E McGlinchey, Katie A McLaughlin, Samuel A McLean, Sarah McLeay, Divya Mehta, William P Milberg, Mark W Miller, Rajendra A Morey, Charles Phillip Morris, Ole Mors, Preben B Mortensen, Benjamin M Neale, Elliot C Nelson, Merete Nordentoft, Sonya B Norman, Meaghan O’Donnell, Holly K Orcutt, Matthew S Panizzon, Edward S Peters, Alan L Peterson, Matthew Peverill, Robert H Pietrzak, Melissa A Polusny, John P Rice, Stephan Ripke, Victoria B Risbrough, Andrea L Roberts, Alex O Rothbaum, Barbara O Rothbaum, Peter Roy-Byrne, Ken Ruggiero, Ariane Rung, Bart PF Rutten, Nancy L Saccone, Sixto E Sanchez, Dick Schijven, Soraya Seedat, Antonia V Seligowski, Julia S Seng, Christina M Sheerin, Derrick Silove, Alicia K Smith, Jordan W Smoller, Scott R Sponheim, Dan J Stein, Jennifer S Stevens
发表日期
2019/10/8
期刊
Nature communications
卷号
10
期号
1
页码范围
4558
出版商
Nature Publishing Group UK
简介
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for …
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CM Nievergelt, AX Maihofer, T Klengel, EG Atkinson… - Nature communications, 2019