作者
Andrew R Davies, James A Gossage, Janine Zylstra, Fredrik Mattsson, Jesper Lagergren, Nick Maisey, Elizabeth C Smyth, David Cunningham, William H Allum, Robert C Mason
发表日期
2014/9/20
期刊
Journal of Clinical Oncology
卷号
32
期号
27
页码范围
2983-2990
出版商
American Society of Clinical Oncology
简介
Purpose
Neoadjuvant chemotherapy is established in the management of most resectable esophageal and esophagogastric junction adenocarcinomas. However, assessing the downstaging effects of chemotherapy and predicting response to treatment remain challenging, and the relative importance of tumor stage before and after chemotherapy is debatable.
Methods
We analyzed consecutive resections for esophageal or esophagogastric junction adenocarcinomas performed at two high-volume cancer centers in London between 2000 and 2010. After standard investigations and multidisciplinary team consensus, all patients were allocated a clinical tumor stage before treatment, which was compared with pathologic stage after surgical resection. Survival analysis was conducted using Kaplan-Meier analysis and Cox regression analysis.
Results
Among 584 included patients, 400 patients (68%) received …
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