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A computer based system and method of visualizing a region using multiple image data sets is provided. The method includes acquiring? rst volumetric image data of a region and acquiring at least second volumetric image data of the region. The? rst image data is generally selected such that the structural features of the region are readily visualized. At least one control point is determined in the region using an identi? able structural characteristic discernable in the? rst volumetric image data. The at least one control point is also located in the at least second image data of the region such that the? rst image data and the at least second image data can be registered to one another using the at least one control point. Once the image data sets are registered, the registered? rst image data and at least second image data can be fused into a common display data set. The multiple image data sets have different and …