作者
Elisa Danese, Sara Raimondi, Martina Montagnana, Angela Tagetti, Taimour Langaee, Paola Borgiani, Cinzia Ciccacci, Antonio J Carcas, Alberto M Borobia, Hoi Y Tong, Cristina Dávila‐Fajardo, Mariana Rodrigues Botton, Stephane Bourgeois, Panos Deloukas, Michael D Caldwell, Jim K Burmester, Richard L Berg, Larisa H Cavallari, Katarzyna Drozda, Min Huang, Li‐Zi Zhao, Han‐Jing Cen, Rocio Gonzalez‐Conejero, Vanessa Roldan, Yusuke Nakamura, Taisei Mushiroda, Inna Y Gong, Richard B Kim, Keita Hirai, Kunihiko Itoh, Carlos Isaza, Leonardo Beltrán, Enrique Jiménez‐Varo, Marisa Cañadas‐Garre, Alice Giontella, Marianne K Kringen, Kari Bente Foss Haug, Hye Sun Gwak, Kyung Eun Lee, Pietro Minuz, Ming Ta Michael Lee, Steven A Lubitz, Stuart Scott, Cristina Mazzaccara, Lucia Sacchetti, Ece Genç, Mahmut Özer, Anil Pathare, Rajagopal Krishnamoorthy, Andras Paldi, Virginie Siguret, Marie‐Anne Loriot, Vijay Kumar Kutala, Guilherme Suarez‐Kurtz, Jamila Perini, Josh C Denny, Andrea H Ramirez, Balraj Mittal, Saurabh Singh Rathore, Hersh Sagreiya, Russ Altman, Mohamed Hossam A Shahin, Sherief I Khalifa, Nita A Limdi, Charles Rivers, Aditi Shendre, Chrisly Dillon, Ivet M Suriapranata, Hong‐Hao Zhou, Sheng‐Lan Tan, Vacis Tatarunas, Vaiva Lesauskaite, Yumao Zhang, Anke H Maitland‐van der Zee, Talitha I Verhoef, Anthonius de Boer, Monica Taljaard, Carlo Federico Zambon, Vittorio Pengo, Jieying Eunice Zhang, Munir Pirmohamed, Julie A Johnson, Cristiano Fava
发表日期
2019/6
期刊
Clinical Pharmacology & Therapeutics
卷号
105
期号
6
页码范围
1477-1491
简介
The cytochrome P450 (CYP)4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta‐analysis at the individual patients level to capture the possible effect of ethnicity, gene—gene interaction, or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta‐analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients’ data. The final collection consists of 15,754 patients split into a derivation and validation cohort. The CYP4F2*3 polymorphism was consistently associated with an increase in mean coumarin dose (+9% (95% confidence interval (CI) 7–10%), with a higher effect in women, in patients taking acenocoumarol, and in white patients. The inclusion of the CYP4F2*3 in dosing …
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E Danese, S Raimondi, M Montagnana, A Tagetti… - Clinical Pharmacology & Therapeutics, 2019