作者
Camilo A Rojas-Carranza, Rosa Helena Bustos-Cruz, Carmen Juliana Pino-Pinzón, Yeimy Viviana Ariza-Marquez, Rosa Margarita Gómez-Bello, Marisa Canadas-Garre
发表日期
2018/4/1
来源
Current pharmaceutical design
卷号
24
期号
15
页码范围
1695-1710
出版商
Bentham Science Publishers
简介
Diabetes mellitus (DM) is the most commonly occurring cause of neuropathy around the world and is beginning to grow in countries where there is a risk of obesity. DM Type II, (T2DM) is a common age-related disease and is a major health concern, particularly in developed countries in Europe where the population is aging. T2DM is a chronic disease which is characterised by hyperglycemia, hyperinsulinemia and insulin resistance, together with the body's inability to use glucose as energy. Such metabolic disorder produces a chronic inflammatory state, as well as changes in lipid metabolism leading to hypertriglyceridemia, thereby producing chronic deterioration of the organs and premature morbidity and mortality. The pathology's effects increase cerebral damage, leading to the rapid onset of neurodegenerative diseases. Hyperglycemia causes oxidative stress in tissues which are susceptible to the …
引用总数
2017201820192020202120222023202425461010106
学术搜索中的文章
CA Rojas-Carranza, RH Bustos-Cruz, CJ Pino-Pinzón… - Current pharmaceutical design, 2018