作者
Laura Jane Smyth, Marisa Cañadas-Garre, Ruaidhri C Cappa, Alexander P Maxwell, Amy Jayne McKnight
发表日期
2019/4/1
来源
BMJ open
卷号
9
期号
4
页码范围
e026777
出版商
British Medical Journal Publishing Group
简介
Background
Chronic kidney disease (CKD) is defined by abnormalities in kidney structure and/or function present for more than 3 months. Worldwide, both the incidence and prevalence rates of CKD are increasing. The renin-angiotensin-aldosterone system (RAAS) regulates fluid and electrolyte balance through the kidney. RAAS activation is associated with hypertension, which is directly implicated in causation and progression of CKD. RAAS blockade, using drugs targeting individual RAAS mediators and receptors, has proven to be renoprotective.
Objectives
To assess genomic variants present within RAAS genes, ACE, ACE2, AGT, AGTR1, AGTR2 and REN, for association with CKD.
Design and data sources
A systematic review and meta-analysis of observational research was performed to evaluate the RAAS gene polymorphisms in CKD using both PubMed and Web of Science databases with publication date …
学术搜索中的文章
LJ Smyth, M Cañadas-Garre, RC Cappa, AP Maxwell… - BMJ open, 2019