作者
Marisa Cañadas-Garre, Patricia Becerra-Massare, Martín López de la Torre-Casares, Jesús Villar-del Moral, Susana Céspedes-Mas, Ricardo Vílchez-Joya, Teresa Muros-de Fuentes, Carlos García-Calvente, Gonzalo Piédrola-Maroto, Miguel A López-Nevot, Rosa Montes-Ramírez, José M Llamas-Elvira
发表日期
2012/5/1
期刊
Annals of surgery
卷号
255
期号
5
页码范围
986-992
出版商
LWW
简介
Objectives:
To evaluate prospectively the usefulness of the routine determination of BRAF T1799A mutation on thyroid fine-needle aspiration biopsy (FNAB) to detect cytopathology false negative papillary thyroid carcinomas (PTC) and, therefore, as a tool to improve the sensitivity of the preoperative cytopathological diagnosis of PTC in thyroid nodules.
Background:
FNAB is the most reliable diagnostic test to discriminate between malignant and benign thyroid nodules, but nondiagnostic results remain a clinical management dilemma. BRAF T1799A mutation is the most prevalent genetic alteration in thyroid cancers and is specific for PTC, characteristics that make it the most potentially helpful genetic tool to improve the diagnostic accuracy of FNAB.
Methods:
An exhaustive recruitment of all patients subjected to thyroid FNAB in our institution during 4 years was performed. BRAF T1799A mutation was determined on …
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