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The network mobility (NEMO) basic support protocol is designed to support NEMO management, and to ensure communication continuity between nodes in mobile networks. However, in nested mobile networks, NEMO suffers from the pinball routing problem, which results in long packet transmission delays. To solve the problem, we propose a domain-based route optimization (DRO) scheme that incorporates a domain-based network architecture and ad hoc routing protocols for route optimization. DRO also improves the intra-domain handoff performance, reduces the convergence time during route optimization, and avoids the out-of-sequence packet problem. A detailed performance analysis and simulations were conducted to evaluate the scheme. The results demonstrate that DRO outperforms existing mechanisms in terms of packet transmission delay (i.e., better route-optimization), intra-domain …