作者
Mitra Tavakoli, Cristian Quattrini, Caroline Abbott, Panagiotis Kallinikos, Andrew Marshall, Joanne Finnigan, Philip Morgan, Nathan Efron, Andrew JM Boulton, Rayaz A Malik
发表日期
2010/8/1
期刊
Diabetes care
卷号
33
期号
8
页码范围
1792-1797
出版商
American Diabetes Association
简介
OBJECTIVE
The accurate quantification of human diabetic neuropathy is important to define at-risk patients, anticipate deterioration, and assess new therapies.
RESEARCH DESIGN AND METHODS
A total of 101 diabetic patients and 17 age-matched control subjects underwent neurological evaluation, neurophysiology tests, quantitative sensory testing, and evaluation of corneal sensation and corneal nerve morphology using corneal confocal microscopy (CCM).
RESULTS
Corneal sensation decreased significantly (P = 0.0001) with increasing neuropathic severity and correlated with the neuropathy disability score (NDS) (r = 0.441, P < 0.0001). Corneal nerve fiber density (NFD) (P < 0.0001), nerve fiber length (NFL), (P < 0.0001), and nerve branch density (NBD) (P < 0.0001) decreased significantly with increasing neuropathic severity and correlated with NDS …
引用总数
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M Tavakoli, C Quattrini, C Abbott, P Kallinikos… - Diabetes care, 2010