作者
Bing Yu, Mary B Roberts, Laura M Raffield, Seyedeh Maryam Zekavat, Ngoc Quynh H Nguyen, Mary L Biggs, Michael R Brown, Gabriel Griffin, Pinkal Desai, Adolfo Correa, Alanna C Morrison, Amil M Shah, Abhishek Niroula, Md Mesbah Uddin, Michael C Honigberg, Benjamin L Ebert, Bruce M Psaty, Eric A Whitsel, JoAnn E Manson, Charles Kooperberg, Alexander G Bick, Christie M Ballantyne, Alex P Reiner, Pradeep Natarajan, Charles B Eaton, National Heart, Lung, and Blood Institute TOPMed Consortium
发表日期
2021/7/6
期刊
Journal of the American College of Cardiology
卷号
78
期号
1
页码范围
42-52
出版商
American College of Cardiology Foundation
简介
Background
Age-related clonal hematopoiesis of indeterminate potential (CHIP), defined as clonally expanded leukemogenic sequence variations (particularly in DNMT3A, TET2, ASXL1, and JAK2) in asymptomatic individuals, is associated with cardiovascular events, including recurrent heart failure (HF).
Objectives
This study sought to evaluate whether CHIP is associated with incident HF.
Methods
CHIP status was obtained from whole exome or genome sequencing of blood DNA in participants without prevalent HF or hematological malignancy from 5 cohorts. Cox proportional hazards models were performed within each cohort, adjusting for demographic and clinical risk factors, followed by fixed-effect meta-analyses. Large CHIP clones (defined as variant allele frequency >10%), HF with or without baseline coronary heart disease, and left ventricular ejection fraction were evaluated in secondary analyses …
学术搜索中的文章
B Yu, MB Roberts, LM Raffield, SM Zekavat… - Journal of the American College of Cardiology, 2021