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Water is the most precious resource to sustain the life on earth. Rapid industrialization and urban development results in inclusion of variety of pollutants into rivers. In the present study, a comparison of characteristics of water quality with respect to heavy metal (Fe, Al, Mn and Se) and their interrelationships with some physiological parameters during different seasons of year 2015 has been investigated flowing through the two geographical regions, namely Kurdistan region (Chamsaghez, Chamkhorkhoreh, Jaghatoo Rivers) and West Azarbaijan Region (Sarough River), in Zarrineh river basin one of the most important and longest rivers in the Lake Urmia basin in Iran which branches from the mountains of Chehelcheshmeh at the being of Kurdistan province. All observed values of Se in spring, observation of Al in 14 stations, observation of Fe in 11 stations and observation of Mn in 9 stations exceed WHO standard …