作者
Susan J Jordan, Renhua Na, Sharon E Johnatty, Lauren A Wise, Hans Olov Adami, Louise A Brinton, Chu Chen, Linda S Cook, Luigino Dal Maso, Immaculata De Vivo, Jo L Freudenheim, Christine M Friedenreich, Carlo La Vecchia, Susan E McCann, Kirsten B Moysich, Lingeng Lu, Sara H Olson, Julie R Palmer, Stacey Petruzella, Malcolm C Pike, Timothy R Rebbeck, Fulvio Ricceri, Harvey A Risch, Carlotta Sacerdote, Veronica Wendy Setiawan, Todd R Sponholtz, Xiao Ou Shu, Amanda B Spurdle, Elisabete Weiderpass, Nicolas Wentzensen, Hannah P Yang, Herbert Yu, Penelope M Webb
发表日期
2017/6/1
期刊
Obstetrics & Gynecology
卷号
129
期号
6
页码范围
1059-1067
出版商
LWW
简介
OBJECTIVE: To investigate the association between breastfeeding and endometrial cancer risk using pooled data from 17 studies participating in the Epidemiology of Endometrial Cancer Consortium.
METHODS: We conducted a meta-analysis with individual-level data from three cohort and 14 case–control studies. Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the association between breastfeeding and risk of endometrial cancer using multivariable logistic regression and pooled using random-effects meta-analysis. We investigated between-study heterogeneity with I 2 and Q statistics and metaregression.
RESULTS: After excluding nulliparous women, the analyses included 8,981 women with endometrial cancer and 17,241 women in a control group. Ever breastfeeding was associated with an 11% reduction in risk of endometrial cancer (pooled OR 0.89, 95% CI 0.81–0.98 …
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SJ Jordan, R Na, SE Johnatty, LA Wise, HO Adami… - Obstetrics & Gynecology, 2017