作者
Michael J Hawrylycz, Ed S Lein, Angela L Guillozet-Bongaarts, Elaine H Shen, Lydia Ng, Jeremy A Miller, Louie N Van De Lagemaat, Kimberly A Smith, Amanda Ebbert, Zackery L Riley, Chris Abajian, Christian F Beckmann, Amy Bernard, Darren Bertagnolli, Andrew F Boe, Preston M Cartagena, M Mallar Chakravarty, Mike Chapin, Jimmy Chong, Rachel A Dalley, Barry David Daly, Chinh Dang, Suvro Datta, Nick Dee, Tim A Dolbeare, Vance Faber, David Feng, David R Fowler, Jeff Goldy, Benjamin W Gregor, Zeb Haradon, David R Haynor, John G Hohmann, Steve Horvath, Robert E Howard, Andreas Jeromin, Jayson M Jochim, Marty Kinnunen, Christopher Lau, Evan T Lazarz, Changkyu Lee, Tracy A Lemon, Ling Li, Yang Li, John A Morris, Caroline C Overly, Patrick D Parker, Sheana E Parry, Melissa Reding, Joshua J Royall, Jay Schulkin, Pedro Adolfo Sequeira, Clifford R Slaughterbeck, Simon C Smith, Andy J Sodt, Susan M Sunkin, Beryl E Swanson, Marquis P Vawter, Derric Williams, Paul Wohnoutka, H Ronald Zielke, Daniel H Geschwind, Patrick R Hof, Stephen M Smith, Christof Koch, Seth GN Grant, Allan R Jones
发表日期
2012/9/20
期刊
Nature
卷号
489
期号
7416
页码范围
391-399
出版商
Nature Publishing Group UK
简介
Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources to complement genomic sequence data and to correlate functional and genetic brain architecture. Here we describe the generation and analysis of a transcriptional atlas of the adult human brain, comprising extensive histological analysis and comprehensive microarray profiling of ∼900 neuroanatomically precise subdivisions in two individuals. Transcriptional regulation varies enormously by anatomical location, with different regions and their constituent cell types displaying robust molecular signatures that are highly conserved between individuals. Analysis of differential gene expression and gene co-expression relationships demonstrates that brain-wide variation strongly reflects the distributions of major cell classes such as neurons, oligodendrocytes, astrocytes and microglia. Local neighbourhood relationships …
引用总数
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