作者
Christian Steidl, Tang Lee, Sohrab P Shah, Pedro Farinha, Guangming Han, Tarun Nayar, Allen Delaney, Steven J Jones, Javeed Iqbal, Dennis D Weisenburger, Martin A Bast, Andreas Rosenwald, Hans-Konrad Muller-Hermelink, Lisa M Rimsza, Elias Campo, Jan Delabie, Rita M Braziel, James R Cook, Ray R Tubbs, Elaine S Jaffe, Georg Lenz, Joseph M Connors, Louis M Staudt, Wing C Chan, Randy D Gascoyne
发表日期
2010/3/11
期刊
New England Journal of Medicine
卷号
362
期号
10
页码范围
875-885
出版商
Massachusetts Medical Society
简介
Background
Despite advances in treatments for Hodgkin's lymphoma, about 20% of patients still die from progressive disease. Current prognostic models predict the outcome of treatment with imperfect accuracy, and clinically relevant biomarkers have not been established to improve on the International Prognostic Score.
Methods
Using gene-expression profiling, we analyzed 130 frozen samples obtained from patients with classic Hodgkin's lymphoma during diagnostic lymph-node biopsy to determine which cellular signatures were correlated with treatment outcome. We confirmed our findings in an independent cohort of 166 patients, using immunohistochemical analysis.
Results
Gene-expression profiling identified a gene signature of tumor-associated macrophages that was significantly associated with primary treatment failure (P=0.02). In an independent cohort of patients, we found that an increased …
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C Steidl, T Lee, SP Shah, P Farinha, G Han, T Nayar… - New England Journal of Medicine, 2010