作者
Roland Schmitz, George W Wright, Da Wei Huang, Calvin A Johnson, James D Phelan, James Q Wang, Sandrine Roulland, Monica Kasbekar, Ryan M Young, Arthur L Shaffer, Daniel J Hodson, Wenming Xiao, Xin Yu, Yandan Yang, Hong Zhao, Weihong Xu, Xuelu Liu, Bin Zhou, Wei Du, Wing C Chan, Elaine S Jaffe, Randy D Gascoyne, Joseph M Connors, Elias Campo, Armando Lopez-Guillermo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M Rimsza, Kevin Tay Kuang Wei, Andrew D Zelenetz, John P Leonard, Nancy L Bartlett, Bao Tran, Jyoti Shetty, Yongmei Zhao, Dan R Soppet, Stefania Pittaluga, Wyndham H Wilson, Louis M Staudt
发表日期
2018/4/12
期刊
New England journal of medicine
卷号
378
期号
15
页码范围
1396-1407
出版商
Massachusetts Medical Society
简介
Background
Diffuse large B-cell lymphomas (DLBCLs) are phenotypically and genetically heterogeneous. Gene-expression profiling has identified subgroups of DLBCL (activated B-cell–like [ABC], germinal-center B-cell–like [GCB], and unclassified) according to cell of origin that are associated with a differential response to chemotherapy and targeted agents. We sought to extend these findings by identifying genetic subtypes of DLBCL based on shared genomic abnormalities and to uncover therapeutic vulnerabilities based on tumor genetics.
Methods
We studied 574 DLBCL biopsy samples using exome and transcriptome sequencing, array-based DNA copy-number analysis, and targeted amplicon resequencing of 372 genes to identify genes with recurrent aberrations. We developed and implemented an algorithm to discover genetic subtypes based on the co-occurrence of genetic alterations.
Results
We …
学术搜索中的文章
R Schmitz, GW Wright, DW Huang, CA Johnson… - New England journal of medicine, 2018