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This research paper investigates the transformative impact of machine learning in diabetic healthcare, aiming to enhance predictive modeling and personalized patient care. Focused on a dataset encompassing 10,000 diabetic patients, the study employs various machine learning algorithms to predict and manage diabetic complications, including retinopathy, nephropathy, and cardiovascular diseases. Quantitative analyses reveal compelling insights into the predictive performance of machine learning models. The Random Forest algorithm exhibits an exceptional accuracy of 85.6%, surpassing Support Vector Machines (81.2%) and Neural Networks (79.5%). Additionally, the Gradient Boosting model demonstrates a remarkable Area Under the Curve (AUC) of 0.92, emphasizing its robustness in predicting diabetic retinopathy. Through cluster analysis, distinct risk groups are identified, allowing for effective risk stratification. High-risk clusters exhibit a 70% probability of cardiovascular complications within 5 years, enabling targeted interventions. The Decision Tree model showcases an 88% sensitivity in early detection of diabetic nephropathy, facilitating timely treatment. Feature importance analysis underscores HbA1c levels, BMI, and diabetes duration as pivotal predictors for diabetic complications. This vital insight aids in personalized risk assessment and tailored treatment strategies for diabetic patients. The study's findings highlight the potential of machine learning in revolutionizing diabetic healthcare by improving predictive accuracy, enabling early diagnosis, and facilitating personalized patient care pathways. These quantitative results …