作者
AA Omar, AID Mavor, AM Jones, S Homer-Vanniasinkam
发表日期
2004/6/1
期刊
European journal of vascular and endovascular surgery
卷号
27
期号
6
页码范围
666-672
出版商
WB Saunders
简介
Background
A number of different treatment approaches have been recommended for the treatment of venous ulceration, including local ulcer treatment, compression and drug therapy. Recent advances in tissue engineering have resulted in living tissues being developed for cutaneous wound repair and skin replacement. The aim of this pilot study was to compare the rate of healing of venous ulcers in patients treated with Dermagraft (a human fibroblast-derived dermal replacement) and compression therapy or compression therapy alone.
Methods
A total of 18 patients with venous ulceration of the leg were recruited into the pilot study. Ten patients were treated with Dermagraft and compression therapy, and eight patients were treated with compression therapy alone. Healing was assessed by ulcer tracing and computerised planimetry. Skin perfusion was measured by laser Doppler.
Results
Five (50%) of the …
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