作者
Rebecca R Gray, Joe Parker, Philippe Lemey, Marco Salemi, Aris Katzourakis, Oliver G Pybus
发表日期
2011/12
期刊
BMC evolutionary biology
卷号
11
页码范围
1-10
出版商
BioMed Central
简介
Background
Hepatitis C virus (HCV) is a rapidly-evolving RNA virus that establishes chronic infections in humans. Despite the virus' public health importance and a wealth of sequence data, basic aspects of HCV molecular evolution remain poorly understood. Here we investigate three sets of whole HCV genomes in order to directly compare the evolution of whole HCV genomes at different biological levels: within- and among-hosts. We use a powerful Bayesian inference framework that incorporates both among-lineage rate heterogeneity and phylogenetic uncertainty into estimates of evolutionary parameters.
Results
Most of the HCV genome evolves at ~0.001 substitutions/site/year, a rate typical of RNA viruses. The antigenically-important E1/E2 genome region evolves particularly quickly, with correspondingly high rates of positive selection, as inferred …
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RR Gray, J Parker, P Lemey, M Salemi, A Katzourakis… - BMC evolutionary biology, 2011