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The process of agricultural simulation using APSIM requires input meteorological data to be prepared in a specific format and the simulation setting file to be ready before the simulation processing starts. Because of possible time savings when conducting large number of simulations at once, it is preferable to create all the input and settings files for all the simulations beforehand and process the simulations in batches as large as possible. This article specifically deals with the data acquisition, transformation and preparation process. It also outlines initial testing and computing time estimations and discusses scheduling, parallel processing and other possible simulation optimization methods..