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OBJECTIVES:

The inflammatory bowel diseases (IBDs) emerged after industrialization. We studied whether ambient air pollution levels were associated with the incidence of IBD.

METHODS:

The health improvement network (THIN) database in the United Kingdom was used to identify incident cases of Crohn's disease (n= 367) or ulcerative colitis (n= 591), and age-and sex-matched controls. Conditional logistic regression analyses assessed whether IBD patients were more likely to live in areas of higher ambient concentrations of nitrogen dioxide (NO 2), sulfur dioxide (SO 2), and particulate matter< 10μm (PM 10), as determined by using quintiles of concentrations, after adjusting for smoking, socioeconomic status, non-steroidal anti-inflammatory drugs (NSAIDs), and appendectomy. Stratified analyses investigated effects by age.

RESULTS:

Overall, NO 2, SO 2, and PM 10 were not associated with the risk of IBD …