作者
Natalie A Molodecky, Shian Soon, Doreen M Rabi, William A Ghali, Mollie Ferris, Greg Chernoff, Eric I Benchimol, Remo Panaccione, Subrata Ghosh, Herman W Barkema, Gilaad G Kaplan
发表日期
2012/1/1
来源
Gastroenterology
卷号
142
期号
1
页码范围
46-54. e42
出版商
WB Saunders
简介
BACKGROUND & AIMS
We conducted a systematic review to determine changes in the worldwide incidence and prevalence of ulcerative colitis (UC) and Crohn's disease (CD) in different regions and with time.
METHODS
We performed a systematic literature search of MEDLINE (1950–2010; 8103 citations) and EMBASE (1980–2010; 4975 citations) to identify studies that were population based, included data that could be used to calculate incidence and prevalence, and reported separate data on UC and/or CD in full manuscripts (n = 260). We evaluated data from 167 studies from Europe (1930–2008), 52 studies from Asia and the Middle East (1950–2008), and 27 studies from North America (1920–2004). Maps were used to present worldwide differences in the incidence and prevalence of inflammatory bowel diseases (IBDs); time trends were determined using joinpoint regression.
RESULTS
The highest …
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