作者
Rita Del Pinto, Davide Pietropaoli, Apoorva K Chandar, Claudio Ferri, Fabio Cominelli
发表日期
2015/11/1
来源
Inflammatory bowel diseases
卷号
21
期号
11
页码范围
2708-2717
出版商
Oxford University Press
简介
Background
Vitamin D plays a role in several immune-mediated diseases, but its association with inflammatory bowel disease (IBD) is unclear. We conducted a systematic review and meta-analysis to assess the association between IBD and vitamin D deficiency.
Methods
We searched electronic databases from inception to December 2014 for observational studies reporting the presence of vitamin D deficiency (defined as serum 25-hydroxycholecalciferol [25(OH)D] level of ≤20 ng/mL) in IBD patients and having a control group without IBD. Odds ratios (ORs) were combined using a random-effects model. Meta-regression was performed using latitude as a moderator. Study quality was assessed using the Newcastle–Ottawa scale.
Results
Out of 816 citations, 14 eligible studies were identified, comprising 1891 participants (938 IBD cases and 953 controls …
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