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Aim. To evaluate the relationship between platelet activation and cognitive impairment in patients with metabolic syndrome (NCEP—ATP I II criteria).

Methods. We studied 80 patients (74±6 year, 49 F) with metabolic syndrome but without evidence of cerebrovascular disease and/or overt dementia. Copitive functions have been explored by MMSE, TMTA and TMTB. The scores of psychometric tests have been then transformed to generate a composite z score. Sixty healthy subjects (72±4 year, 32 F) without evidence of dementia or cardiovascular disease, were studied. Circulating levels of sCD40L and P-selectin were studied as indexes of platelet activation. Furthermore, we analyzed circulating levels of 8-iso-prostaglandin (PG) F2alfa, a well accepted index of lipid peroxidation and a potential determinant of platelet activation.

Results. Patients with metabolic syndrome exhibited worse cognitiveperformance (z score …