作者
Daniela Mastroiacovo, Catherine Kwik-Uribe, Davide Grassi, Stefano Necozione, Angelo Raffaele, Luana Pistacchio, Roberta Righetti, Raffaella Bocale, Maria Carmela Lechiara, Carmine Marini, Claudio Ferri, Giovambattista Desideri
发表日期
2015/3/1
期刊
The American journal of clinical nutrition
卷号
101
期号
3
页码范围
538-548
出版商
Elsevier
简介
Background: Recent evidence has indicated that flavanol consumption may have many health benefits in humans, including improved cognitive activities.
Objective: The aim was to evaluate the effect of flavanol consumption on cognitive performance in cognitively intact elderly subjects.
Design: This was a double-blind, controlled, parallel-arm study conducted in 90 elderly individuals without clinical evidence of cognitive dysfunction who were randomly assigned to consume daily for 8 wk a drink containing 993 mg [high flavanol (HF)], 520 mg [intermediate flavanol (IF)], or 48 mg [low flavanol (LF)] cocoa flavanols (CFs). Cognitive function was assessed at baseline and after 8 wk by using the Mini-Mental State Examination (MMSE), the Trail Making Test (TMT) A and B, and the Verbal Fluency Test (VFT).
Results: The changes in MMSE score in response to the 3 different treatments were not different. In contrast, there …
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D Mastroiacovo, C Kwik-Uribe, D Grassi, S Necozione… - The American journal of clinical nutrition, 2015