作者
Gian Paolo Rossi, Giampaolo Bernini, Chiara Caliumi, Giovambattista Desideri, Bruno Fabris, Claudio Ferri, Chiara Ganzaroli, Gilberta Giacchetti, Claudio Letizia, Mauro Maccario, Francesca Mallamaci, Massimo Mannelli, Mee-Jung Mattarello, Angelica Moretti, Gaetana Palumbo, Gabriele Parenti, Enzo Porteri, Andrea Semplicini, Damiano Rizzoni, Ermanno Rossi, Marco Boscaro, Achille Cesare Pessina, Franco Mantero, PAPY Study Investigators
发表日期
2006/12/5
期刊
Journal of the American College of Cardiology
卷号
48
期号
11
页码范围
2293-2300
出版商
American College of Cardiology Foundation
简介
Objectives
We prospectively investigated the prevalence of curable forms of primary aldosteronism (PA) in newly diagnosed hypertensive patients.
Background
The prevalence of curable forms of PA is currently unknown, although retrospective data suggest that it is not as low as commonly perceived.
Methods
Consecutive hypertensive patients referred to 14 hypertension centers underwent a diagnostic protocol composed of measurement of Na+and K+in serum and 24-h urine, sitting plasma renin activity, and aldosterone at baseline and after 50 mg captopril. The patients with an aldosterone/renin ratio >40 at baseline, and/or >30 after captopril, and/or a probability of PA (by a logistic discriminant function) ≥50% underwent imaging tests and adrenal vein sampling (AVS) or adrenocortical scintigraphy to identify the underlying adrenal pathology. An aldosterone-producing adenoma (APA) was diagnosed in patients …
引用总数
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GP Rossi, G Bernini, C Caliumi, G Desideri, B Fabris… - Journal of the American College of Cardiology, 2006