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In this paper, a new optimization framework is presented for the joint design of user selection, power allocation, and precoding in multi-cell multi-user multiple-input multiple-output (MU-MIMO) systems when imperfect channel state information at transmitter (CSIT) is available. By representing the joint optimization variables in a higher-dimensional space, the weighted sum-spectral efficiency maximization is formulated as the maximization of the product of Rayleigh quotients. Although this is still a non-convex problem, a computationally efficient algorithm, referred to as generalized power iteration precoding (GPIP), is proposed. The algorithm converges to a stationary point (local maximum) of the objective function and therefore it guarantees the first-order optimality of the solution. By adjusting the weights in the weighted sum-spectral efficiency, the GPIP yields a joint solution for user selection, power allocation, and …