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The development of an unconstrained sensing technique using PVDF films as sensory material for monitoring the heart beats and respiration of premature infants is reported. A sensor consists of a 1× 4 array of PVDF films is developed. The sensor is placed on the bed to pick up the fluctuation of the pressure on the bed caused by the respiratory movement and heart beats of a premature infant. Wavelet multi-resolution decomposition is used for simultaneous detection of heart beats and respiration. Simultaneous real-time detection of both the respiration and heartbeats has been verified through clinical experiments.