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The intensification of microreactions is important for biological and chemical reactions with microliter volumes as reaction units, including microliter bioassay or protein synthesis. At the micro/nanoscale, the fluid flow is usually located in the laminar region, making the interaction between different layers of material more difficult. In the absence of external intervention, the microscale transport of substances is dominated by passive diffusion, leading to a lower mixing efficiency and longer reaction times, which is disadvantageous for reactions requiring timeliness, such as microliter bioassays. Therefore, the intensification of microreactions is essential. Here, a dual magnetic–photothermal microreaction control platform was created, based on the cooperative roles of a close-loop photothermally controlled magnetically active nanoswarm (PMANS) as a nanostir for quick fluid mixing and as a nanoheating agent for the …