作者
Anoop SV Shah, Atul Anand, Fiona E Strachan, Amy V Ferry, Kuan Ken Lee, Andrew R Chapman, Dennis Sandeman, Catherine L Stables, Philip D Adamson, Jack PM Andrews, Mohamed S Anwar, John Hung, Alistair J Moss, Rachel O'Brien, Colin Berry, Iain Findlay, Simon Walker, Anne Cruickshank, Alan Reid, Alasdair Gray, Paul O Collinson, Fred S Apple, David A McAllister, Donogh Maguire, Keith AA Fox, David E Newby, Christopher Tuck, Ronald Harkess, Richard A Parker, Catriona Keerie, Christopher J Weir, Nicholas L Mills, Lucy Marshall, Stacey D Stewart, Takeshi Fujisawa, Catalina A Vallejos, Athanasios Tsanas, Mischa Hautvast, Jean McPherson, Lynn McKinlay, Jonathan Malo, Colin M Fischbacher, Bernard L Croal, Stephen J Leslie, Allan Walker, Tony Wackett, Roma Armstrong, Laura Stirling, Claire MacDonald, Imran Sadat, Frank Finlay, Heather Charles, Pamela Linksted, Stephen Young, Bill Alexander, Chris Duncan
发表日期
2018/9/15
期刊
The Lancet
卷号
392
期号
10151
页码范围
919-928
出版商
Elsevier
简介
Background
High-sensitivity cardiac troponin assays permit use of lower thresholds for the diagnosis of myocardial infarction, but whether this improves clinical outcomes is unknown. We aimed to determine whether the introduction of a high-sensitivity cardiac troponin I (hs-cTnI) assay with a sex-specific 99th centile diagnostic threshold would reduce subsequent myocardial infarction or cardiovascular death in patients with suspected acute coronary syndrome.
Methods
In this stepped-wedge, cluster-randomised controlled trial across ten secondary or tertiary care hospitals in Scotland, we evaluated the implementation of an hs-cTnI assay in consecutive patients who had been admitted to the hospitals' emergency departments with suspected acute coronary syndrome. Patients were eligible for inclusion if they presented with suspected acute coronary syndrome and had paired cardiac troponin measurements from the …
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ASV Shah, A Anand, FE Strachan, AV Ferry, KK Lee… - The Lancet, 2018