作者
Elvis A Akwo, Hua-Chang Chen, Ge Liu, Jefferson L Triozzi, Ran Tao, Zhihong Yu, Cecilia P Chung, Ayush Giri, T Alp Ikizler, C Michael Stein, Edward D Siew, QiPing Feng, Cassianne Robinson-Cohen, Adriana M Hung
发表日期
2022/8/1
期刊
Kidney International Reports
卷号
7
期号
8
页码范围
1802-1818
出版商
Elsevier
简介
Introduction
Common variants in the UMOD gene are considered an evolutionary adaptation against urinary tract infections (UTIs) and have been implicated in kidney stone formation, chronic kidney disease (CKD), and hypertension. However, differences in UMOD variant-phenotype associations across population groups are unclear.
Methods
We tested associations between UMOD/PDILT variants and up to 1528 clinical diagnosis codes mapped to phenotype groups in the Million Veteran Program (MVP), using published phenome-wide association study (PheWAS) methodology. Associations were tested using logistic regression adjusted for age, sex, and 10 principal components of ancestry. Bonferroni correction for multiple comparisons was applied.
Results
Among 648,593 veterans, mean (SD) age was 62 (14) years; 9% were female, 19% Black, and 8% Hispanic. In White patients, the rs4293393 UMOD risk …
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EA Akwo, HC Chen, G Liu, JL Triozzi, R Tao, Z Yu… - Kidney International Reports, 2022