作者
Vivian K Kawai, Mingjian Shi, Ge Liu, QiPing Feng, WeiQi Wei, Cecilia P Chung, Theresa L Walunas, Adam S Gordon, James G Linneman, Scott J Hebbring, John B Harley, Nancy J Cox, Dan M Roden, C Michael Stein, Jonathan D Mosley
发表日期
2021/7
期刊
Lupus
卷号
30
期号
8
页码范围
1264-1272
出版商
SAGE Publications
简介
Objectives
To test the hypothesis that genetic predisposition to systemic lupus erythematosus (SLE) increases the risk of cardiometabolic disorders.
Methods
Using 41 single nucleotide polymorphisms (SNPs) associated with SLE, we calculated a weighted genetic risk score (wGRS) for SLE. In a large biobank we tested the association between this wGRS and 9 cardiometabolic phenotypes previously associated with SLE: atrial fibrillation, ischemic stroke, coronary artery disease, type 1 and type 2 diabetes, obesity, chronic kidney disease, hypertension, and hypercholesterolemia. Additionally, we performed a phenome-wide association analysis (pheWAS) to discover novel clinical associations with a genetic predisposition to SLE. Findings were replicated in the Electronic Medical Records and Genomics (eMERGE) Network. To further define the association between SLE-related risk alleles and the selected …
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VK Kawai, M Shi, G Liu, QP Feng, WQ Wei, CP Chung… - Lupus, 2021