作者
Laura L Daniel, Alyson L Dickson, Jacy T Zanussi, Tyne W Miller‐Fleming, Peter S Straub, Wei‐Qi Wei, W Dale Plummer, William D Dupont, Ge Liu, Prathima Anandi, Tyler S Reese, Kelly A Birdwell, Vivian K Kawai, Adriana M Hung, Nancy J Cox, QiPing Feng, C Michael Stein, Cecilia P Chung
发表日期
2022/4
期刊
Clinical and Translational Science
卷号
15
期号
4
页码范围
859-865
简介
TPMT and NUDT15 variants explain less than 25% of azathioprine‐associated myelotoxicity. There are 25 additional genes in the thiopurine pathway that could also contribute to azathioprine myelotoxicity. We hypothesized that among TPMT and NUDT15 normal metabolizers, a score combining the genetically predicted expression of other proteins in the thiopurine pathway would be associated with a higher risk for azathioprine discontinuation due to myelotoxicity. We conducted a retrospective cohort study of new users of azathioprine who were normal TPMT and NUDT15 metabolizers. In 1201 White patients receiving azathioprine for an inflammatory disease, we used relaxed Least Absolute Shrinkage and Selection Operator (LASSO) regression to select genes that built a score for discontinuing azathioprine due to myelotoxicity. The score incorporated the predicted expression of AOX1 and NME1. Patients in …
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LL Daniel, AL Dickson, JT Zanussi, TW Miller‐Fleming… - Clinical and Translational Science, 2022