作者
Tetsufumi Kanazawa, Stephen J Glatt, Atsushi Tsutsumi, Hiroki Kikuyama, Jun Koh, Hiroshi Yoneda, Ming T Tsuang
发表日期
2007/1/5
期刊
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
卷号
144
期号
1
页码范围
113-116
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Increasing evidence has supported the hypothesis of a neurodevelopmental component in the etiology of schizophrenia. Recently, several independent microarray gene expression studies have revealed downregulated expression of myelin‐related genes in the postmortem brains of schizophrenia patients. Complete myelination of the cortex has been observed to occur in late adolescence and early adulthood, which is typically the age of onset of schizophrenia. ERBB3 is a gene which has not only been found to be downregulated in schizophrenia simultaneously in three microarray studies, but also is a strong candidate because of its potential role in neurodevelopment as a receptor of NRG1. Therefore, we performed association analysis of seven nonsynonymous SNPs in this gene. Two SNPs in ERBB3 (rs773123 and rs2271188) were polymorphic in our samples, neither of which showed significant evidence …
引用总数
2007200820092010201120122013201420152016201720182019202020212022133134121111
学术搜索中的文章
T Kanazawa, SJ Glatt, A Tsutsumi, H Kikuyama, J Koh… - American Journal of Medical Genetics Part B …, 2007