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Zirconium-89 (⁸⁹Zr, t_1/2 = 78.4 h) liquid target (LT) production offers an approach to introduce this positron-emitting isotope to cyclotron centres without the need for a separate solid target (ST) production set up. We compared the production, purification, and antibody radiolabeling yields of ⁸⁹Zr-(LT) and ⁸⁹Zr-(ST), and assessed the feasibility of ⁸⁹Zr-(LT) for preclinical PET/CT.

⁸⁹Zr-(ST) production was performed with an ⁸⁹Y foil on a TR 19 cyclotron at 13.8 MeV. For LT production; an aqueous solution of yttrium nitrate (Y(NO₃)₃ · 6H₂O) was irradiated on a TR 13 cyclotron at 12 MeV. ⁸⁹Zr was purified from the ST or LT material with hydroxamate resin, and used to radiolabel p-SCN-Bn-Deferoxamine (DFO)-conjugated Trastuzumab. MicroPET-CT imaging was performed at 1, 3 and 5 days post-injection of ⁸⁹Zr-DFO-Trastuzumab from ST or LT with biodistribution analysis on day 5.