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Objective:

Ghrelin and leptin play a role in control of food intake and adiposity but mechanisms regulating these hormones in man are poorly defined and evidence that dietary fats may have adverse effects is inconclusive. We investigated whether high-fat meals, which differed in saturated fatty acid (SFA) content acutely modified these hormones.

Design:

Randomised, double-blind, crossover trial. A high-fat (HF) test meal (59±4 g fat; 71% of energy as fat) was given for breakfast on two occasions. Meals comprised either high (∼ 70: 30) or low (∼ 55: 45) saturated: unsaturated fatty acid (SFA: USFA) ratio. Fasting and postprandial measurements of serum total ghrelin (RIA), leptin (enzyme-linked immunosorbent assay (ELISA)) and insulin (RIA) were made over 6 h. Postprandial measurements were also made at 10 and 24 h following a fat-exclusion lunch, snack and dinner.

Subjects:

A total of 18 lean, healthy men …