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Rapid growth of internet applications fueled the need for securing information and computers. Encryption algorithms play vital role to secure information. This paper provides comparison of most common encryption algorithms namely: DES, Blowfish, CAST-128, RC6, IDEA. Performance evaluation is carried out on the basis of execution time and throughput. These algorithms has different key and block size. DES, IDEA, Blowfish, CAST-128 has block size of 64 bits. DES has key Size of 64 bits while IDEA, Blowfish, CAST-128 has key size of 128 bits. RC6 has Key size and Block size of 128 bits. Simulation results are provided to demonstrate the effectiveness of each algorithm.