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We propose a highly sensitive hollow core photonic crystal fiber (HCPCF) for liquid sensing in the terahertz (THz) region. Asymmetrical rectangular shaped air holes in the cladding region along with Topas glass as a background material is used to get high sensitivity and low confinement loss. The full vector finite element method (FEM) is used to calculate relative sensitivity and other parameters of the proposed liquid sensor where frequency range is taken from 1 THz to 2 THz. The strut distance variations are also studied in this study to find out minimum strut length to make the proposed sensor fabrication friendly. Numerical analysis shows the maximum relative sensitivity of 91.42% for water, 92.55% for acetic acid and 94.03% for chloroform at optimal conditions along with the minimum confinement loss of 1.06 × 10⁻⁹cm⁻¹ for water, 2.02 × 10⁻¹⁰cm⁻¹ for acetic acid and 1.39 × 10⁻¹¹cm⁻¹ for chloroform …