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In recent years, logistics industry has received extensive attention with the development of online shopping. Logistics distribution is the core of logistics industry. Scientifically rational logistics distribution can save delivery cost and improve customer satisfaction. Therefore, it is very important to study the two echelon vehicle routing problem (2E-VRP) in logistics distribution.Artificial bee colony algorithm has strong global optimization ability and the performance of genetic algorithm depends on the choice of the initial solution. Based on large-scale neighbour search, this paper proposes ABCGA algorithm. ABCGA algorithm makes use of artificial bee colony algorithm for the first time to solve the 2E-VRP problem. Then, genetic algorithm is used to optimize the original optimal solution. ABCGA algorithm has many advantages such as stable effect, high efficiency and so on. This paper experiments on 93 test problems …