作者
Saul N Faust, Richard Haynes, Christine E Jones, Natalie Staplin, Elizabeth Whittaker, Thomas Jaki, Ed Juszczak, Enti Spata, Mandy Wan, Alasdair Bamford, Paul Dimitri, Adam Finn, John Furness, Athimalaipet V Ramanan, Christopher Gale, Katrina Cathie, Simon Drysdale, Jolanta Bernatoniene, Clare Murray, Charles C Roehr, Paul Fleming, Andrew Riordan, Srini Bandi, Deepthi Jyothish, Jennifer Evans, Marieke Emonts, Dominic Kelly, Nazima Pathan, Patrick Davies, Rosie Hague, Louisa Pollock, Malcolm G Semple, Leon Peto, J Kenneth Baillie, Maya Buch, Katie Jeffery, Marian Knight, Wei Shen Lim, Alan Montgomery, Aparna Mukherjee, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Marion Mafham, Jonathan Emberson, Martin J Landray, Peter W Horby, Lucy Chappell, Jeremy Day, DV Dung, NN Quang, E Burhan, B Alisjahbana, J Koirala, S Basnet, E Kestelyn, B Basnyat, P Gyanwali, RL Hamers, P Sandercock, J Darbyshire, D DeMets, R Fowler, D Lalloo, M Munavvar, I Roberts, A Warris, J Wittes, A Craddock-Bamford, J Barton, A Basoglu, R Brown, W Brudlo, E Denis, L Fletcher, S Howard, S Musini, K Taylor, G Cui, B Goodenough, A King, M Lay, D Murray, W Stevens, K Wallendszus, R Welsh, C Crichton, J Davies, R Goldacre, C Harper, F Knight, M Nunn, H Salih, J Welch, M Campbell, G Pessoa-Amorim, M Zayed, J Wiles, G Bagley, S Cameron, S Chamberlain, B Farrell, H Freeman, A Kennedy, A Whitehouse, S Wilkinson, C Wood, C Reith, K Davies, H Halls, L Holland, R Truell, K Wilson, Emma Lingwood, L Howie, M Lunn, Penelope Rodgers, J Amuasi, K Baird, T Bao, M Bittaye, J Bonney, U D'Alessandro, M Dhimal, T Huyen, A Jagne, A Karkey, O Maiga, E Matey, B Nadjm, J Nel, S Pant, K Puspatriani, M Rahardjani, S Raijal, H Rees, A Rimainar, C Roberts, A Rocca, S Shrestha, E Usuf, C Vidaillic, F Wulandari, A Alexander, M Amezaga, C Armah, A Asghar, P Aubrey, K Barker-Williams, A Barnard
发表日期
2024/3/1
期刊
The Lancet Child & Adolescent Health
卷号
8
期号
3
页码范围
190-200
出版商
Elsevier
简介
Background
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as multisystem inflammatory syndrome in children (MIS-C) emerged in April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess the effect of intravenous immunoglobulin or corticosteroids compared with usual care on duration of hospital stay for children with PIMS-TS and to compare tocilizumab (anti-IL-6 receptor monoclonal antibody) or anakinra (anti-IL-1 receptor antagonist) with usual care for those with inflammation refractory to initial treatment.
Methods
We did this randomised, controlled, open-label, platform trial in 51 hospitals in the UK. Eligible patients were younger than 18 years and had been admitted to hospital for PIMS-TS. In the first randomisation, patients were randomly assigned (1: 1: 1) to usual care (no additional treatments), usual care plus …
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SN Faust, R Haynes, CE Jones, N Staplin, E Whittaker… - The Lancet Child & Adolescent Health, 2024