作者
Ming Zhao, Yin Zhou, Bochen Zhu, Mengjie Wan, Tingting Jiang, Qiqun Tan, Yan Liu, Juqing Jiang, Shuaihantian Luo, Yixin Tan, Haijing Wu, Paul Renauer, Maria del Mar Ayala Gutiérrez, Maria Jesús Castillo Palma, Rafaela Ortega Castro, Concepción Fernández-Roldán, Enrique Raya, Raquel Faria, Claudia Carvalho, Marta E Alarcón-Riquelme, Zhongyuan Xiang, Jinwei Chen, Fen Li, Guanghui Ling, Hongjun Zhao, Xiangping Liao, Youkun Lin, Amr H Sawalha, Qianjin Lu
发表日期
2016/11/1
期刊
Annals of the rheumatic diseases
卷号
75
期号
11
页码范围
1998-2006
出版商
BMJ Publishing Group Ltd
简介
Objective
Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease with limited reliable diagnostic biomarkers. We investigated whether gene methylation could meet sensitivity and specificity criteria for a robust biomarker.
Methods
IFI44L promoter methylation was examined using DNA samples from a discovery set including 377 patients with SLE, 358 healthy controls (HCs) and 353 patients with rheumatoid arthritis (RA). Two independent sets including 1144 patients with SLE, 1350 HCs, 429 patients with RA and 199 patients with primary Sjögren's syndrome (pSS) were used for validation.
Results
Significant hypomethylation of two CpG sites within IFI44L promoter, Site1 (Chr1: 79 085 222) and Site2 (Chr1: 79 085 250; cg06872964), was identified in patients with SLE compared with HCs, patients with RA and patients with pSS. In a comparison between patients with SLE and HCs included in …
学术搜索中的文章
M Zhao, Y Zhou, B Zhu, M Wan, T Jiang, Q Tan, Y Liu… - Annals of the rheumatic diseases, 2016